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A relatively new class of drugs known as sitagliptin includes the brand name Januvia and is used in the treatment of type 2 diabetes. Januvia—along with others in the same class—has been shown in some studies to bring significant risks to patients taking the drug. Januvia blocks or inhibits DPP-4 in the body, allowing the patient’s system to better control glucose levels as well as increasing the amount of insulin produced by the pancreas when the blood sugar is high. These DPP-4 blockers can also reduce the amount of sugar produced by the liver when the body does not need the excess.
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