Monday, January 16, 2012

What is Metallosis?

Metallosis occurs when metallic debris builds up in the periprosthetic soft tissues. In the case of the DePuy ASR Acetabular system, the two parts of the hip implant abraded against one another, creating friction and releasing metallic ions of cobalt and chromium into the body.

Those microscopic metal ions cause an autoimmune response. The immune system identifies the metal ions as foreign bodies and automatically inflames the area around the debris. The body is essentially trying to "trap" the foreign particles in the inflamed area so that the metal can't spread to the rest of the body. In the case of the DePuy hip implant, it appears that the immune system sends inflammatory cells to the synovial membrane as well, causing synovitis. Synovitis is generally quite painful, since the membrane is too inflamed to allow the joint to rotate properly.

Metallosis can be complicated by metal sensitivity, which is essentially an allergic reaction to metal. The normal autoimmune response to foreign matter in the body is to inflame the area and attack the foreign cells. When the body is hypersensitive to a particular substance (like metal), the immune system overreacts and multiplies its efforts to eliminate the foreign body. In the process, normal healthy tissue can get caught in the crossfire as the body mounts an ever-growing campaign against the foreign body.

In patients with a DePuy ASR Acetabular System, the immune system is fighting a losing battle, even after its efforts are multiplied through metal sensitivity. Your white blood cells (leukocytes) attack any foreign organism, but they also "tag" and remember the organisms that have attempted to invade before and come up with secretions designed to wipe out those specific invaders.

In the ASR hip implant, the device's friction constantly releases new metal ions into the bloodstream, which means the immune system continually receives a message that its efforts are not enough to eliminate the foreign matter.

A simple analogy for the metallosis is a food allergy, which occurs when the body identifies a food as so dangerous to the body that its autoimmune reaction is exaggerated. Essentially, it identifies the food as a poison and reacts strongly so that the brain will realize the food is dangerous and move the body away from it. In extreme allergies, the body's immune response can be so overly strong that it can actually kill the person.

Generally, this sort of over-reaction occurs if the immune system is completely unfamiliar with a foreign body and can find no parallels with other objects it has encountered in the past. It can also occur if the body is over-subjected to the object; for example, it is possible to give yourself an allergy to just about any food if you consume excess amounts for months at a time.

Symptoms of metallosis generally include pain around the site of the implant, pseudo tumors (a mass of inflamed cells that resembles a tumor but is in fact merely collected fluid), and a noticeable rash that indicates dying tissue. The damaged and inflamed tissue can also contribute to loosening the implant or causing dislocation, since the tissue that would normally hold the implant in place is weakened.

Women, the small in stature, and the obese are at greater risk for metallosis because their body structure causes more tension on the implant and contributes to the release of the metal ions into the bloodstream.

Print
Author: Andrew Sullo
0 Comments

Categories: ImportedNumber of views: 2125

Tags: hip Metallosis

Please login or register to post comments.
I understand that by submitting my contact information to Sullo & Sullo LLP for review, I consent to receive telephone, email, and text messages regarding this legal matter as well as marketing for any other potential legal matters in the future without limitation unless terminated by me in writing. Standard messaging and data rates apply.
Receive an Immediate Response
ANDREW SULLO IS A TOP 100 NATIONAL TRIAL LAWYER 2013 • 2014 • 2015 • 2016 • 2017 • 2018 • 2019
Obtener una Respuesta Inmediata
Andrew Sullo – 100 Mejores Abogados Nacional | 2013 • 2014 • 2015 • 2016 • 2017


#1

ON YELP'S LIST OF THE
BEST 10 LAWYERS IN HOUSTON*

*APRIL 2019 THROUGH SEP 2020



Andrew Sullo has been named a

TOP 100 NATIONAL TRIAL LAWYER*
2013-2020

*BY THE NATIONAL TRIAL LAWYERS

 

CALL NOW FOR A FREE LEGAL CONSULTATION
(800) 730-7607
CALL NOW FOR A FREE LEGAL CONSULTATION (713) 839-9026 CALL NOW FOR A FREE LEGAL CONSULTATION (713) 335-9485


Andrew Sullo is a recipient of the

AVVO CLIENT'S CHOICE AWARD*
FOR 2019

*GIVEN BY AVVO


Justice

Andrew Sullo is a Member of the

AMERICAN ASSOCIATION OF JUSTICE
2013-2020

*GRANTED BY THE AAJ

 

IF YOU OR A LOVED ONE WERE SERIOUSLY INJURED DUE TO THE NEGLIGENCE OF ANOTHER, CONTACT SULLO & SULLO IMMEDIATELY.
CALL NOW
(800) 730-7607
CALL NOW
(713) 839-9026
CALL NOW
(713) 335-9485

GET LEGAL HELP