With the recent recalls of all-metal and partial metal hip implants due to metal toxicity and implant failure, recipients of the Stryker Rejuvenate could be forced to undergo revision surgery to replace the recalled hip implant device. For the general population, the levels of cobalt and chromium in the bloodstream-from naturally occurring sources—are approximately 0.5 parts per billion. Patients who have been implanted with a device with metal parts could find those levels considerably higher. The generally accepted “danger” level is considered to be anything over 7 parts per billion however many doctors believe that number is much lower—between 2 and 3 parts per billion.

DePuy Orthopedics, along with their parent company, Johnson & Johnson, issued a recall of their ASR XL Acetabular Hip System, along with the ASR Hip Resurfacing System in August of 2010. This recall was implemented following a flurry of adverse event reports among recipients of one of these two hip implants. At the time of the recall DePuy and Johnson and Johnson acknowledged that the ASR XL and the ASR Hip Resurfacing System had a higher-than-expected rate of failure—as much as 12% within a short time after implantation. At the time of the recall, DePuy stated that the ASR could loosen or misalign and that recipients of the ASR were at a higher risk for infection, bone fracture, dislocation, metallosis, metal toxicity and pain. 

Smith & Nephew is well-known for its innovative contributions to the design of hip implants. For example, in 2003 the company introduced their own exclusive alloy comprised of oxidized zirconium. This oxidized zirconium appears to increase the hip implant durability and, unlike ceramic components does not fracture. According to Smith and Nephew the release of metal ions and debris are significantly reduced when this particular alloy is used in the hip implant components. Like many other hip implant manufacturers, however, Smith and Nephew has experienced trouble with another device—the metal liner used in the R3 Acetabular system was recalled on June 1, 2012. 

Like many other metal-on-metal hip implant manufacturers, Wright Medical Technology has experienced problems with its Profemur and the Wright-Conserve Total Hip System, including metallosis and metal toxicity among recipients.